Evaluation of popular drug information resources on clinically useful and actionable pharmacogenomic information

Authors

  • Jennifer S. Chang Pharmacy Student (at the time of the study), Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, 533 Parnassus Avenue, U-585, Box 0622, San Francisco, CA 94143-0622
  • Duyen-Anh Pham Pharmacy Student (at the time of the study), Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, 533 Parnassus Avenue, U-585, Box 0622, San Francisco, CA 94143-0622
  • Maithao T. Dang Pharmacy Student (at the time of the study), Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, 533 Parnassus Avenue, U-585, Box 0622, San Francisco, CA 94143-0622
  • Yiting Lu Pharmacy Student (at the time of the study), Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, 533 Parnassus Avenue, U-585, Box 0622, San Francisco, CA 94143-0622
  • Sheri VanOsdol Assistant Professor of Clinical Pharmacy (at the time of the study), Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, 533 Parnassus Avenue, U-585, Box 0622, San Francisco, CA 94143-0622
  • Jaekyu Shin Associate Professor of Clinical Pharmacy, Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco, 533 Parnassus Avenue, U-585, Box 0622, San Francisco, CA 94143-0622

Keywords:

Pharmacogenomics, Biomarkers, Drug Information Services, Genetic Testing

Abstract

Background: Pharmacogenomics is the study of how genes affect a person’s response to drugs. This descriptive study assessed whether popular drug information resources provide clinically useful pharmacogenomic (PGx) information.

Methods: Four resources (package inserts, Lexicomp, Micromedex 2.0, and Epocrates) were evaluated for information about twenty-seven drugs.

Results: There was wide variability of PGx information. Whereas Lexicomp included relevant PGx biomarker information for all 27 drugs, Epocrates did in less than 50% of the drugs. None of the resources had monographs that fully incorporated Clinical Pharmacogenomics Implementation Consortium (CPIC) recommendations in more than 30% of the drugs.

Conclusion: Lexicomp appears to be most useful PGx drug information resource, but none of the resources are sufficient.

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Published

2016-01-01

Issue

Vol. 104 No. 1 (2016): January 2016

Section

Research Communications