Evaluation of popular drug information resources on clinically useful and actionable pharmacogenomic information

Jennifer S. Chang, Duyen-Anh Pham, Maithao T. Dang, Yiting Lu, Sheri VanOsdol, Jaekyu Shin

Abstract


Background: Pharmacogenomics is the study of how genes affect a person’s response to drugs. This descriptive study assessed whether popular drug information resources provide clinically useful pharmacogenomic (PGx) information.

Methods: Four resources (package inserts, Lexicomp, Micromedex 2.0, and Epocrates) were evaluated for information about twenty-seven drugs.

Results: There was wide variability of PGx information. Whereas Lexicomp included relevant PGx biomarker information for all 27 drugs, Epocrates did in less than 50% of the drugs. None of the resources had monographs that fully incorporated Clinical Pharmacogenomics Implementation Consortium (CPIC) recommendations in more than 30% of the drugs.

Conclusion: Lexicomp appears to be most useful PGx drug information resource, but none of the resources are sufficient.


Keywords


Pharmacogenomics, Biomarkers, Drug Information Services, Genetic Testing

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Copyright (c) 2017 Jennifer S. Chang, Duyen-Anh Pham, Maithao T. Dang, Yiting Lu, Sheri VanOsdol, Jaekyu Shin

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This work is licensed under a Creative Commons Attribution 4.0 International License.